Among his previous positions are Advisor to the President of Philadelphia University for Research, Development and Information Technology, President and Chair of Board of Directors of the Society for Molding and Simulation International, SCS, Senior Vice President of SCS, Dean of the College of Engineering at Prince Sultan University, Chair and tenured Professor at the Department of Computer and Information Science and Director of the MS Graduate Program in Data Analytics at Fordham university, Chair and tenured Professor of the Department of Computer Science and Director of the Graduate Program at Monmouth University, Tenured Full Professor at King Abdullah II School of Information Technology, University of Jordan, Founding Dean and Professor, College of Computing and Informatics at The University of Sharjah, UAE and distinguished Professor at the Indian Institute of Technology-Dhanbad. He is also The PR of China Ministry of Education Distinguished Overseas Professor at the University of Science and Technology Beijing, China and an Honorary Distinguished Professor at the Amity University- A Global University and an Honorary Distinguished Professor at KASIT, University of Jordan.

He is now the Chair and Professor of Computer Science Department and Director of the Cybersecurity Center at the University of Texas- Permian Basin, USA. He has chaired numerous (Over 180) international conferences and has given numerous (Over 180) keynote speeches worldwide. He has served as ABET/CSAB evaluator and on IEEE CS Fellow Evaluation Committee. He has served as IEEE CS Distinguished Speaker/Lecturer and an ACM Distinguished Lecturer. Since 2004 has been serving as an SCS Distinguished Lecturer. He received many best paper awards for his papers including ones from IEEE ICC, IEEE Globecom, AICSA, CITS, SPECTS, DCNET International conferences. He also received Best Paper awards from IEEE Systems Journal in 2018 and in 2019 (2 Best Paper Awards). In 2020, he received 4 best paper awards from IEEE Systems Journal. In 2021, he also received the IEEE Systems best paper award. In 2021, he was ranked by Guide2Research as Number 1 Computer Scientist in UAE in terms of Number of Publications. He has received many best paper awards from IEEE International Conferences. 

He also received many other worldwide awards for his technical contributions including: The 2018 IEEE ComSoc-Technical Committee on Communications Software Technical Achievement Award for contribution to Cybersecurity, Wireless Networks Computer Networks and Modeling and Simulation, SCS prestigious McLeod Founder's Award , Presidential Service Award, SCS Hall of Fame –Lifetime Achievement Award for his technical contribution to modeling and simulation and for his outstanding visionary leadership and dedication to increasing the effectiveness and broadening the applications of modeling and simulation worldwide. He also received the SCS Outstanding Service Award. He was awarded the IEEE CITS Hall of Fame Distinguished and Eminent Award.  In recognition of his significant scientific contribution, Springer published in Feb 2022 a book honoring his contributions in Computing, Informatics, Networking and Cybersecurity. It is entitled: Advances in Computing, Informatics, Networking and Cybersecurity - A Book Honoring Professor Mohammad S. Obaidat’s Significant Scientific Contributions. He is a Life Fellow of IEEE, a Fellow of SCS and a Fellow of AAIA.